Neuronal Plasma Membrane Disruption in Traumatic Brain Injury

iii DEDICATION I would like to thank my parents Alvaro and Vera for a lifetime of support and my wife Heather for making the last five years a great chapter in my life. iv ACKNOWLEDGEMENTS The author would like to acknowledge Jim Ross who manufactured the multi-electrode arrays and aided in techniques such as platinum plating employed in the manufacturing process as well as quantification of electrical outcome by software development. Ciara Caltagirone and Dr. Michael Schumm provided invaluable aid in the in vivo portion of this research with their expertise in animal experimentation. were pivotal in providing technical advice in the membrane disruption assays. Everyone in Dr. LaPlaca's laboratory was helpful in solving various technical issues throughout this process. John Graham and everyone else in the ME machine shop were instrumental in the facilitation in the manufacturing of the devices utilized in this study.